Active Ingredient: Ciprofloxacin
For heteroalkylene groups, heteroatoms can also occupy either or both of the chain termini. Non-limiting examples of such alkoxy groups are methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, tertiary butoxy, pentoxy and the like.
Examples of heteroaryl substituents include 6-membered ring substituents such as pyridyl, pyrazyl, pyrimidinyl, and pyridazinyl; and 5-membered ring substituents such as triazolyl, imidazolyl, furanyl, thiophenyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl,2,3-,2,4-,2,5-, or 1,3,4-oxadiazolyl and isothiazolyl.
The heteroaryl can be optionally substituted, as appropriate, by 1 to 5 suitable substituents as defined herein such as fluoro, chloro, deutero, cyano, trifluoromethyl, C 1-C 6 alkoxy, C 6-C 10 aryloxy, trifluoromethoxy, difluoromethoxy or C 1-C 6 alkyl.
In some instances, the number of atoms in a cyclic substituent containing one or more heteroatoms i.It uses SPI for communication so it can connect to an access point but it cannot be an.
The heteroatoms for this invention are selected from nitrogen, oxygen and sulfur. Metabolites such as these or others formed as part of the natural biochemical process are within the scope of the invention.
Such terms are also defined to include all forms of the compound of Formula I, including hydrates, solvates, isomers, crystalline and non-crystalline forms, isomorphs, polymorphs, tautomers and metabolites thereof.
When the solvent or water is tightly bound, the complex will have a well-defined stoichiometry independent of humidity. In such cases, non-stoichiometry will be the norm.
The compounds of the invention have asymmetric carbon atoms. The use of a solid line to depict bonds to asymmetric carbon atoms is meant to indicate that all possible stereoisomers e.
The use of either a solid or dotted wedge to depict bonds to asymmetric carbon atoms is meant to indicate that only the stereoisomer shown is meant to be included. In those compounds, the use of a solid line to depict bonds to asymmetric carbon atoms is meant to indicate that all possible stereoisomers are meant to be included.
For example, unless stated otherwise, it is intended that the compounds of Formula I can exist as enantiomers and diastereomers or as racemates and mixtures thereof. The use of a solid line to depict bonds to one or more asymmetric carbon atoms in a compound of Formula I and the use of a solid or dotted wedge to depict bonds to other asymmetric carbon atoms in the same compound is meant to indicate that a mixture of diastereomers is present.
Stereoisomers of Formula I include cis and trans isomers, optical isomers such as R and S enantiomers, diastereomers, geometric isomers, rotational isomers, conformational isomers, and tautomers of the compounds of the invention, including compounds exhibiting more than one type of isomerism; and mixtures thereof such as racemates and diastereomeric pairs.
Also included are acid addition or base addition salts wherein the counterion is optically active, for example, D-lactate or L-lysine, or racemic, for example, DL-tartrate or DL-arginine.
All such tautomeric forms are included within the scope of the compounds of the Formula I and the scope of the invention. Tautomers exist as mixtures of a tautomeric set in solution.
In solid form, usually one tautomer predominates. Examples of tautomers are described by Examples 32 and 32 a.
When any racemate crystallizes, crystals of two different types are possible.