Active Ingredient: Azithromycin
Typically, viscosity is reduced by using amount and types of excipients that do not significantly raise the viscosity of the aqueous vehicle.
For example, instead of using sugar, which increases suspension viscosity, as a sweetener, a non-viscosifying sweetener, such as saccharin, aspartame, acesulfame potassium, thaumatin, and monelin, can be used.
In this embodiment, it is preferred that the conversion enhancer comprises at least one flavoring.
Preferably, the powder for oral suspension is in a dosage form of a single use or multiple use bottle. Most preferred the bottle is a 60 cc high density polyethylene HDPE bottle with a child resistant cap.
A specified volume of aqueous vehicle is typically added to the bottle containing the powders for oral suspension and shaken to provide a homogeneous constituted suspension.
It is noted that powders for oral suspension and unit dose packets, of course, are not ingested directly by patients. Rather, they are constituted in a suitable vehicle.
A single dose sachet is designed to be emptied into an aqueous vehicle or alternatively the aqueous vehicle is added to a bottle containing the single dose or multidose powder for oral suspension.
Generally, it is noted that, when a powder for oral suspension is mixed with the aqueous vehicle, the azithromycin contained therein is substantially suspended in the liquid, if constituted according to directions, although the extent of suspension versus solution depends on a number of factors such as pH.
Such bacterial infections and protozoal infections and disorders related to such infections include, but are not limited to, the following: pneumonia, otitis media, sinusitis, bronchitis, tonsillitis, and mastoiditis related to infection by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, or Peptostreptococcus spp.
Sanford et al. The class Mammalia includes, for example, humans, monkeys, chimpanzees, gorillas, cattle, swine, horses, sheep, dogs, cats, mice and rats. In the present invention, the preferred mammal is a human.
Exemplification The present invention will be further illustrated by means of the following examples.
It is to be understood, however, that the invention is not meant to be limited to the details described therein. Louis, Mo. Chicago, Ill. Brooklyn.
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